How can I change it?

When you use Apple’s Mail app on your iPhone to send email, the default signature is “Sent from my iPhone.” But some of us would rather not advertise that fact with every email. You may even prefer to change it to something more personal. If so, don’t bother poking around in the Mail app itself.

Instead, go to Settings > Mail > Signature. In here you can change the signature to anything you like or delete it entirely. For those of you with multiple email accounts configured, such as one for work and one for home, you can also set a different signature for each.